Senior Scientist, In vitro Pharmacology

Location : Oslo, Norway

Department : Research & Development

Reports to : Director RLT Discovery

Position Overview

Actithera is a radiopharmaceutical biotech company, co-headquartered in Oslo and Cambridge, Massachusetts, founded in 2021. The company applies a chemistry-first approach to design next-generation radioligand therapies (RLTs) that deliver potent, tumor-focused radiation while sparing healthy tissue—guided by an isotope-agnostic and platform-enabled strategy to optimize tumor retention and therapeutic index. Actithera’s vision is rooted in precision molecular design and a deeply collaborative culture, with a shared mission to transform the lives of cancer patients through innovative science.

We are seeking an experienced and driven Senior Scientist to join our in vitro pharmacology team in Oslo. The Senior Scientist will work side by side in the laboratory with colleagues while also taking a leadership role in designing, executing, and interpreting in vitro studies. This position combines hands-on experimental work with scientific leadership to shape discovery programs and guide junior team members.

Key Responsibilities

• Design, develop, and execute in vitro assays including cell culture, radioligand binding and uptake assays, internalization, efflux, stability, and mechanism-of-action studies including cytotoxicity and DNA damage readouts.
• Lead assay optimization, validation, and troubleshooting to ensure robust and reproducible data.
• Analyze, interpret and present experimental findings as well as scientific insights to project teams, linking in vitro pharmacology to therapeutic potential.
• Mentor and support scientists in experimental execution and data analysis.
• Collaborate cross-functionally with radiochemistry, and in vivo pharmacology groups to integrate in vitro results into program strategy and support ex vivo readouts from pharmacology studies.
• Contribute to publications, patents, and external presentations as appropriate.
• Ensure compliance with radiation safety regulations, actively promoting best practices and maintaining a safe laboratory environment for the team.

Qualifications

What We Offer

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